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KMID : 0377519950200040333
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Chung-Ang Journal of Medicine
1995 Volume.20 No. 4 p.333 ~ p.350
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Blood Cadmium and Zinc and Urinary N-acetyl-β-D-glucosaminidase Activity in Rural Residents Not Exposed to Cadmium
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Ohn Young-Hoon
Park Jung-Duck
Choi Byung-Sun
Hong Yeon-Pyo
Chang Im-Won
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Abstract
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In order to identify the reference value and distribution of blood cadmium, zinc and urinary NAG activity and analyze relationship among them, this study was performed in 102 subjects (male : 35, female : 67) aged 25 to 95 who had not been exposed to cadmium in rural area. The mean values of blood cadmium and zinc were 2.04±0.72 ㎍/ℓ and 5.56±0.97 mg/ℓ, and urinary NAG activity was 2.16±2.66 U/ℓ, 2.38±2.31 U/g creatinine and 2.11±2.60 U/S.G., There were no difference between both sexes in blood cadmium and urinary NAG activities, but blood zinc level was significantly higher in male. Blood cadmium and zinc level were relatively constant by the age, but urinary NAG activity had tendency increasing with the age. Blood cadmium and urinary NAG activity showed log normal distribution while blood zinc showed normal distribution. There were no relation between blood cadmium or blood zinc and urinary NAG activity, but urinary NAG activity in 3 groups classified by the blood cadmium level had increasing tendency with cadmium level. These results suggest that urinary NAG activity can be used as an useful indicator of early changes of kidney function induced by low dose cadmium exposure in cadmium exposed group.
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KEYWORD
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blood, cadmium, zinc, N-acetyl-β-D-glucosaminidase(NAG)
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